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Secondary mitochondrial dysfunction Acquired dysfunction may develop from oxidative stress, inflammation, nutrient deficiency, medication toxicity, toxic exposure, aging, metabolic disease, infection, poor sleep, inactivity or chronic illness

Moving to acellular formats, GelMA micro-spheres fabricated by microfluidics encapsulate MSC-derived exosomes pre-loaded with miR-21

This means proper nutrition, regular exercise, and stress management all play key roles